Within the research focus, aspects to be addressed could be: developing or adapting mammalian cells for use of alternative nitrogen sources and sources of growth factors (cell line optimization/engineering developing high-cell density cell cultures, adapting/influencing both the cells as well as designing and developing fermenter/reactor (cultivation) concepts. This would entail a combination of fermentation technology to be able to grow and differentiate stem cells under controlled conditions together with mammalian cell biology for proper understanding, steering and control of the stem cell fate during cultivation. The focus of the research field to be developed by the Assistant Professor will be on process engineering aspects of large-scale cell cultivation. The new Assistant Professor will strengthen this expertise by developing a new research line focused on mammalian cell biology and fermentation technology, with the goal to address key challenges in development of sustainable, scalable CA processes. The section already harbors extensive expertise in mammalian cell culture, advanced bioprocess monitoring, fermentation and process design. The position will be embedded in the Dutch National Growth Fund CA program (en./growthplan) and based in the Bioprocess Engineering section of TU Delft’s Department of Biotechnology. To address these challenges, TU Delft opens an academic career-track Assistant Professor position on Mammalian Cell Culture for Food Applications. Proper understanding of the metabolism, growth, differentiation of stem cells under industrially relevant, scalable process conditions is needed to be able to operate bioreactor cultivation at high volume and high cell density.
However, development of sustainable, cost-effective processes for cultivating mammalian cells at the huge scale required to meet a substantial fraction of anticipated global meat demands raises interesting scientific and technological challenges. CA may enable transformative reductions in carbon footprint, water usage, environmental impact and animal welfare relative to traditional meat production. Cellular Agriculture (CA) is a new concept in biotechnology that aims to produce meat by producing muscle cells and tissue from animal stems cells rather than from whole animals.
0 kommentar(er)
